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TitleHybrid-2: AnImidazoquinoline Dual Toll-like receptor 7/8 Agonist that Potently Activates Cytokine Production by Human Newborn and Adult Leukocytes
Journal, issue, pagesTo be Published
Publish dateAug 22, 2014 (structure data deposition date)
AuthorsGanapathi, L. / Haren, S.V. / Dowling, D.J. / Bergelson, I. / Shukla, N.M. / Malladi, S.S. / Balakrishna, R. / Tanji, H. / Ohto, U. / Shimizu, T. ...Ganapathi, L. / Haren, S.V. / Dowling, D.J. / Bergelson, I. / Shukla, N.M. / Malladi, S.S. / Balakrishna, R. / Tanji, H. / Ohto, U. / Shimizu, T. / David, S.A. / Levy, O.
External linksSearch PubMed
MethodsX-ray diffraction
Resolution2.1 Å
Structure data

PDB-4r6a:
Crystal structure of human TLR8 in complex with Hybrid-2
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-HB2:
1-(4-amino-2-butyl-1H-imidazo[4,5-c]quinolin-1-yl)-2-methylpropan-2-ol

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsRNA BINDING PROTEIN / RNA recognition / ssRNA / Leucine rich repeat / RNA Receptor / innate immunity / Glycosylation / Secreted / Structure-based Ligand Design / vaccine adjuvants / Antiviral and Antitumor Drug Binding

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