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TitleTAS1440, a histone H3 competitive LSD1 inhibitor, activates both TGF-beta and notch signaling pathways via INSM1 dissociation in neuroendocrine small cell lung cancer
Journal, issue, pagesTo Be Published
Publish dateMay 17, 2023 (structure data deposition date)
AuthorsMachida, T. / Tsukioka, S. / Gong, Y. / Onodera, A. / Nakayama, A. / Hashimoto, N. / Ohkubo, S. / Tanaka, T.
External linksSearch PubMed
MethodsX-ray diffraction
Resolution3.2 Å
Structure data

PDB-8jf5:
Crystal structure of Lysine Specific Demethylase 1 (LSD1) with TAS1440
Method: X-RAY DIFFRACTION / Resolution: 3.2 Å

Chemicals

ChemComp-FAD:
FLAVIN-ADENINE DINUCLEOTIDE / FAD*YM

ChemComp-GOL:
GLYCEROL


ChemComp, No image

ChemComp-UEU:
Unknown entry

Source
  • homo sapiens (human)
KeywordsFLAVOPROTEIN / Histone demethylase

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