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TitleNovel pyrrolo[2,3-f]isoquinoline based MAPKAP-K2 (MK2) inhibitors with potent in vitro and in vivo activity
Journal, issue, pagesTo be Published
Publish dateMar 10, 2010 (structure data deposition date)
AuthorsRevesz, L. / Schlapbach, A. / Aichholz, R. / Feifel, R. / Hawtin, S. / Heng, R. / Hiestand, P. / Jahnke, W. / Koch, G. / Moebitz, H. ...Revesz, L. / Schlapbach, A. / Aichholz, R. / Feifel, R. / Hawtin, S. / Heng, R. / Hiestand, P. / Jahnke, W. / Koch, G. / Moebitz, H. / Scheufler, C. / Velcicky, J. / Huppertz, C.
External linksSearch PubMed
MethodsX-ray diffraction
Resolution2.68 Å
Structure data

PDB-3m42:
Crystal structure of MAPKAP kinase 2 (MK2) complexed with a tetracyclic ATP site inhibitor
Method: X-RAY DIFFRACTION / Resolution: 2.68 Å

Chemicals

ChemComp-MG:
Unknown entry

ChemComp-HGF:
2-[5-(2-methoxyethoxy)pyridin-3-yl]-8,9,10,11-tetrahydro-7H-pyrido[3',4':4,5]pyrrolo[2,3-f]isoquinolin-7-one

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / SMALL MOLECULE INHIBITOR / ATP-SITE KINASE INHIBITOR / NOVARTIS-PRODUCT NVP-BMA086 / ATP-binding / Kinase / Nucleotide-binding / Phosphoprotein / Serine/threonine-protein kinase

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