| タイトル | Structural modifications of alphaGalCer in both lipid and carbohydrate moiety influence activation of murine and human iNKT cells |
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| ジャーナル・号・ページ | To Be Published |
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| 掲載日 | 2015年2月9日 (構造データの登録日) |
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著者 | Birkholz, A. / Nemcovic, M. / Yu, E.D. / Girardi, E. / Wang, J. / Khurana, A. / Pauwels, N. / Franck, R.W. / Tsuji, M. / Howell, A. ...Birkholz, A. / Nemcovic, M. / Yu, E.D. / Girardi, E. / Wang, J. / Khurana, A. / Pauwels, N. / Franck, R.W. / Tsuji, M. / Howell, A. / Calenbergh, S. / Kronenberg, M. / Zajonc, D.M. |
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リンク | PubMedで検索 |
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| 手法 | X線回折 |
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| 解像度 | 2.9 - 3.19 Å |
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| 構造データ | PDB-4y2d: Crystal structure of the mCD1d/7DW8-5/iNKTCR ternary complex 手法: X-RAY DIFFRACTION / 解像度: 3.05 Å PDB-4y4f: Crystal structure of the mCD1d/GCK127/iNKTCR ternary complex 手法: X-RAY DIFFRACTION / 解像度: 3.19 Å PDB-4y4h: Crystal structure of the mCD1d/GCK152/iNKTCR ternary complex 手法: X-RAY DIFFRACTION / 解像度: 3.1 Å PDB-4y4k: Crystal structure of the mCD1d/EF77/iNKTCR ternary complex 手法: X-RAY DIFFRACTION / 解像度: 2.9 Å |
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| 化合物 | ChemComp-NAG: 2-acetamido-2-deoxy-beta-D-glucopyranose
ChemComp-7DW: 11-(4-fluorophenyl)-N-[(2S,3S,4R)-1-(alpha-D-galactopyranosyloxy)-3,4-dihydroxyoctadecan-2-yl]undecanamide
ChemComp-49M: (1R)-1,5-anhydro-1-[(1E,3S,4S,5R)-4,5-dihydroxy-3-(nonacosanoylamino)nonadec-1-en-1-yl]-D-galactitol
ChemComp-49X: (1R)-1,5-anhydro-1-{(1E,3S,4S,5R)-4,5-dihydroxy-3-[(8-phenyloctanoyl)amino]nonadec-1-en-1-yl}-D-galactitol
ChemComp-49Y: (4Z)-9-[(1R,2R)-2-decylcyclopropyl]-N-[(2S,3S,4S)-1-(alpha-D-galactopyranosyloxy)-3,4-dihydroxyoctadecan-2-yl]non-4-enamide
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| 由来 |  mus musculus (ハツカネズミ) homo sapiens (ヒト)
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キーワード | IMMUNE SYSTEM / MHC-fold / Ig-fold / glycolipid antigen presentation / T cell receptor |
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