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Structure paper

TitleCrystal Structure of Human DHFR complexed with NADP and N10formyltetrahydrofolate
Journal, issue, pagesto be published
Publish dateMay 2, 2018 (structure data deposition date)
AuthorsMayclin, S.J. / Dranow, D.M. / Walpole, C. / Lorimer, D.D.
External linksSearch PubMed
MethodsX-ray diffraction
Resolution1.55 Å
Structure data

PDB-6dav:
Crystal Structure of Human DHFR complexed with NADP and N10formyltetrahydrofolate
Method: X-RAY DIFFRACTION / Resolution: 1.55 Å

Chemicals

ChemComp-NAP:
NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE

ChemComp-G3V:
N-(4-{[(2,4-diaminopteridin-6-yl)methyl](hydroxymethyl)amino}benzene-1-carbonyl)-L-glutamic acid

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsOXIDOREDUCTASE / Structure-guided Drug Discovery Consortium / dihydrofolate reductase / hDHFR / NADP

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