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TitleStructural basis of PPARgamma-mediated transcriptional repression by the covalent inverse agonist FX-909
Journal, issue, pagesTo Be Published
Publish dateApr 18, 2025 (structure data deposition date)
AuthorsLaughlin, Z.T. / Arifova, L. / Munoz-Tello, P. / Yu, X. / Dong, J. / Harp, J.M. / Kojetin, D.J.
External linksSearch PubMed
MethodsX-ray diffraction
Resolution2.1 Å
Structure data

PDB-9o9n:
Crystal structure of PPARgamma ligand binding domain (LBD) in complex with NCoR1 corepressor peptide and inverse agonist FX-909
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

Chemicals

PDB-1caa:
X-RAY CRYSTAL STRUCTURES OF THE OXIDIZED AND REDUCED FORMS OF THE RUBREDOXIN FROM THE MARINE HYPERTHERMOPHILIC ARCHAEBACTERIUM PYROCOCCUS FURIOSUS

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsNUCLEAR PROTEIN / nuclear / receptor / inverse agonist / cancer / fx-909 / ppar / pparg / ncor / corepressor

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