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TitleCrystal structures of the native, substrate- bound and inhibited forms of Mycobacterium tuberculosis imidazole glycerol phosphate dehydratase
Journal, issue, pagesActa Crystallogr. ,Sect. D, Year 2013
Publish dateAug 24, 2012 (structure data deposition date)
AuthorsAhangar, M.S. / Vyas, R. / Nasir, N. / Biswal, B.K.
External linksSearch PubMed
MethodsX-ray diffraction
Resolution2.02 - 2.3 Å
Structure data

PDB-4gqu:
Crystal structure of HisB from Mycobacterium tuberculosis
Method: X-RAY DIFFRACTION / Resolution: 2.02 Å

PDB-4lom:
Crystal Structure of Mycobacterium tuberculosis HisB in complex with its substrate
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

PDB-4lpf:
Crystal structure of Mycobacterium tuberculosis imidazole glycerol phosphate dehydratase in complex with an inhibitor
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

Chemicals

ChemComp-MN:
Unknown entry

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-HOH:
WATER

ChemComp-IYP:
(2R,3S)-2,3-dihydroxy-3-(1H-imidazol-5-yl)propyl dihydrogen phosphate

ChemComp-3TR:
3-AMINO-1,2,4-TRIAZOLE

Source
  • mycobacterium tuberculosis (bacteria)
  • mycobacterium tuberculosis h37rv (bacteria)
KeywordsLYASE / Mycobacterium tuberculosis / Histidine biosynthesis / Manganese / Class- Alpha and Beta Fold- Ribosomal protein S5 domain 2-like Super family-Ribosomal protein S5 domain 2-like Family- Imidazole glycerol phoshate dehydratase Domain- Imidazole glycerol phosphate dehydratase / Dehydratase / ENZYME-SUBSTRATE COMPLEX

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