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Structure paper

TitleEngineered nucleoside 2'-deoxyribonsyltransferase enzymes enable scalable synthesis of diverse nucleoside analogues
Journal, issue, pagesTo Be Published
Publish dateMar 11, 2024 (structure data deposition date)
AuthorsTang, P. / Harding, C.J. / Czekster, C.M.
External linksSearch PubMed
MethodsX-ray diffraction
Resolution1.77 - 2.51 Å
Structure data

PDB-9emw:
Nucleoside 2'deoxyribosyltransferase from Chroococcidiopsis thermalis PCC 7203 Y7F Mutant bound to ImmH-Forodesine
Method: X-RAY DIFFRACTION / Resolution: 2.51 Å

PDB-9emx:
Nucleoside 2'deoxyribosyltransferase from Chroococcidiopsis thermalis PCC 7203 Double Mutant Y7F A9S bound to Cordycepin
Method: X-RAY DIFFRACTION / Resolution: 1.77 Å

Chemicals

ChemComp-IMH:
1,4-DIDEOXY-4-AZA-1-(S)-(9-DEAZAHYPOXANTHIN-9-YL)-D-RIBITOL / inhibitor*YM

ChemComp-HOH:
WATER

ChemComp-3AD:
3'-DEOXYADENOSINE

Source
  • chroococcidiopsis thermalis pcc 7203 (bacteria)
KeywordsTRANSFERASE / Mutant / Clofarabine / Ligand

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