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Structure paper

TitleEnhancing the potency of sirtuin 2 inhibitors through rational functional group modulations targeting NAD+ co-factor interactions
Journal, issue, pagesTo Be Published
Publish dateJul 25, 2025 (structure data deposition date)
AuthorsWirawan, R. / Frei, M. / Heider, A. / Papenkordt, N. / Friedrich, F. / Wein, T. / Jung, M. / Groll, M. / Huber, E.M. / Bracher, F.
External linksSearch PubMed
MethodsX-ray diffraction
Resolution1.45 - 2.15 Å
Structure data

PDB-9s44:
Human Histone Deacetylase SIRT2
Method: X-RAY DIFFRACTION / Resolution: 2.15 Å

PDB-9s46:
Human SIRT2 in Complex with RW-78
Method: X-RAY DIFFRACTION / Resolution: 1.45 Å

PDB-9s48:
Human SIRT2 in Complex with RW-80
Method: X-RAY DIFFRACTION / Resolution: 1.45 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-HOH:
WATER

PDB-1jlk:
Crystal structure of the Mn(2+)-bound form of response regulator Rcp1

ChemComp-EDO:
1,2-ETHANEDIOL

PDB-1jll:
Crystal Structure Analysis of the E197betaA Mutant of E. coli SCS

ChemComp-ACT:
ACETATE ION

Source
  • homo sapiens (human)
KeywordsHYDROLASE / Lysine deacetylase / NAD+-dependant enzyme / Histone modification / Epigenetics / Inhibitior

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