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TitleA novel, specific BTK inhibitor antagonizes BCR and FcgR signaling and suppresses inflammatory arthritis
Journal, issue, pagesTo be Published
Publish dateSep 27, 2010 (structure data deposition date)
AuthorsDi Paolo, J. / Huang, T. / Balazs, M. / Barbosa, J. / Barck, K.H. / Bravo, B. / Carano, R.A.D. / Darrow, J. / Davies, D.R. / DeForge, L.E. ...Di Paolo, J. / Huang, T. / Balazs, M. / Barbosa, J. / Barck, K.H. / Bravo, B. / Carano, R.A.D. / Darrow, J. / Davies, D.R. / DeForge, L.E. / Diehl, L. / Ferrando, R. / Gallion, S.L. / Gianetti, A.M. / Gribling, P. / Hurez, V. / Hymowitz, S.G. / Jones, R. / Kropf, J.E. / Lee, W.P. / Maciejewski, P.M. / Mitchell, S.A. / Rong, H. / Staker, B.L. / Whitney, J.A. / Yeh, S. / Young, W. / Yu, C. / Zhang, J. / Reif, K. / Currie, K.S.
External linksSearch PubMed
MethodsX-ray diffraction
Resolution2.3 Å
Structure data

PDB-3p08:
Crystal structure of the human BTK kinase domain
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / b-cell / alpha/beta / kinase / phosphorylation / cytosol

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