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Titlec-KIT kinase domain in complex with ponatinib
Journal, issue, pagesTo Be Published
Publish dateFeb 15, 2024 (structure data deposition date)
AuthorsTeuber, A. / Niggenaber, J. / Kleinboelting, S.B. / Landel, I. / Warmuth, J. / Busick, D. / Mueller, M.P. / Bauer, S. / Rauh, D.
External linksSearch PubMed
MethodsX-ray diffraction
Resolution2.2 Å
Structure data

PDB-8s17:
c-KIT kinase domain in complex with ponatinib
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

Chemicals

ChemComp-0LI:
3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzam

ChemComp-CL:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / stem cell factor receptor / GIST / inhibitor / gatekeeper mutation / resistance

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