EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	Structure-based design of ligands of the m6A-RNA reader YTHDC1
ジャーナル・号・ページ	Eur J Med Chem Rep, Vol. 5, Page 100057-, Year 2022
掲載日	2020年4月6日 (構造データの登録日)
著者	Li, Y. / Bedi, R.K. / Nai, F. / von Roten, V. / Dolbois, A. / Zalesak, F. / Nachawati, R. / Huang, D. / Caflisch, A.
リンク	Eur J Med Chem Rep / PubMedで検索
手法	X線回折
解像度	1.1 - 1.9 Å
構造データ	PDB-6yke: Crystal structure of YTHDC1 with compound DHU_DC1_038 手法: X-RAY DIFFRACTION / 解像度: 1.52 Å PDB-6yki: Crystal structure of YTHDC1 with compound DHU_DC1_092 手法: X-RAY DIFFRACTION / 解像度: 1.3 Å PDB-6ykj: Crystal structure of YTHDC1 with compound DHU_DC1_125 手法: X-RAY DIFFRACTION / 解像度: 1.6 Å PDB-6ykz: Crystal structure of YTHDC1 with compound DHU_DC1_234 手法: X-RAY DIFFRACTION / 解像度: 1.2 Å PDB-6yl8: Crystal structure of YTHDC1 with compound DHU_DC1_011 手法: X-RAY DIFFRACTION / 解像度: 1.5 Å PDB-6yl9: Crystal structure of YTHDC1 with compound DHU_DC1_085 手法: X-RAY DIFFRACTION / 解像度: 1.5 Å PDB-6yni: Crystal structure of YTHDC1 with compound DHU_DC1_036 手法: X-RAY DIFFRACTION / 解像度: 1.36 Å PDB-6ynj: Crystal structure of YTHDC1 with compound DHU_DC1_046 手法: X-RAY DIFFRACTION / 解像度: 1.5 Å PDB-6ynk: Crystal structure of YTHDC1 with compound DHU_DC1_068 手法: X-RAY DIFFRACTION / 解像度: 1.3 Å PDB-6ynl: Crystal structure of YTHDC1 with compound DHU_DC1_078 手法: X-RAY DIFFRACTION / 解像度: 1.5 Å PDB-6ynm: Crystal structure of YTHDC1 with compound DHU_DC1_096 手法: X-RAY DIFFRACTION / 解像度: 1.5 Å PDB-6ynp: Crystal structure of YTHDC1 with compound T96C1 手法: X-RAY DIFFRACTION / 解像度: 1.1 Å PDB-6yoq: Crystal structure of YTHDC1 with compound VVR_DC1_002 手法: X-RAY DIFFRACTION / 解像度: 1.3 Å PDB-7p87: Crystal structure of YTHDC1 with compound YLI_DC1_001 手法: X-RAY DIFFRACTION / 解像度: 1.3 Å PDB-7p88: Crystal structure of YTHDC1 with compound YLI_DC1_002 手法: X-RAY DIFFRACTION / 解像度: 1.5 Å PDB-7p8a: Crystal structure of YTHDC1 with compound YLI_DC1_003 手法: X-RAY DIFFRACTION / 解像度: 1.7 Å PDB-7p8b: Crystal structure of YTHDC1 with compound YLI_DC1_006 手法: X-RAY DIFFRACTION / 解像度: 1.2 Å PDB-7p8f: Crystal structure of YTHDC1 with compound YLI_DC1_008 手法: X-RAY DIFFRACTION / 解像度: 1.5 Å PDB-7pj7: Crystal structure of YTHDC1 with compound DHU_DC1_222 手法: X-RAY DIFFRACTION / 解像度: 1.41 Å PDB-7pj8: Crystal structure of YTHDC1 with compound DHU_DC1_225 手法: X-RAY DIFFRACTION / 解像度: 1.4 Å PDB-7pj9: Crystal structure of YTHDC1 with compound DHU_DC1_232 手法: X-RAY DIFFRACTION / 解像度: 1.72 Å PDB-7pja: Crystal structure of YTHDC1 with compound PSI_DC1_002 手法: X-RAY DIFFRACTION / 解像度: 1.85 Å PDB-7pjb: Crystal structure of YTHDC1 with compound PSI_DC1_004 手法: X-RAY DIFFRACTION / 解像度: 1.9 Å PDB-7pjp: Crystal structure of YTHDC1 with compound DHU_DC1_226 手法: X-RAY DIFFRACTION / 解像度: 1.61 Å PDB-7pjq: Crystal structure of YTHDC1 with compound T96 手法: X-RAY DIFFRACTION / 解像度: 1.2 Å
化合物	ChemComp-SO4: SULFATE ION / 硫酸ジアニオン ChemComp-OUQ: (2~{R})-2-(3-fluorophenyl)-5,5-dimethyl-morpholine ChemComp-HOH: WATER ChemComp-OUZ: ~{N}-ethyl-2-[(2~{S},5~{R})-5-methyl-2-phenyl-morpholin-4-yl]ethanamine ChemComp-OUW: ~{N}-methyl-4-(methylamino)pyridine-2-carboxamide ChemComp-OW8: ~{N}-methyl-1,4,5,6-tetrahydrocyclopenta[c]pyrazole-3-carboxamide ChemComp-OWZ: (2~{R},5~{S})-2-(2-chlorophenyl)-5-methyl-morpholine ChemComp-OXB: 3-[(2~{R},5~{S})-2-(2,5-dimethylphenyl)-5-methyl-morpholin-4-yl]propane-1-sulfonamide ChemComp-P0Q: (2~{R},3~{R})-2-(3-chlorophenyl)-3,5,5-trimethyl-morpholine ChemComp-P0N: (2~{R})-2-(2-chlorophenyl)-5,5-dimethyl-morpholine ChemComp-P0K: 6-[[furan-2-ylmethyl(methyl)amino]methyl]-5~{H}-pyrimidine-2,4-dione ChemComp-PEG: DI(HYDROXYETHYL)ETHER / ジエチレングリコ-ル ChemComp-P0Z: 3-[(2~{R})-5,5-dimethyl-2-phenyl-morpholin-4-yl]-~{N}-(methylcarbamoyl)propanamide ChemComp-P1Q: 1-[(2~{R},5~{S})-2-(3-chlorophenyl)-5-methyl-morpholin-4-yl]-3-methoxy-propan-2-ol ChemComp-PJH: ~{N}-methylpyridine-3-carboxamide / N-メチルニコチンアミド ChemComp-CL: Unknown entry / クロリド ChemComp-P5H: 6-methyl-~{N}-[2-(methylsulfonylamino)ethyl]-2-oxidanylidene-3~{H}-pyridine-3-carboxamide ChemComp-ID0: N-methyl-4,5,6,7-tetrahydro-1H-indazole-3-carboxamide ChemComp-OYN: 2-chloranyl-~{N}-methyl-9~{H}-purin-6-amine / 2-クロロ-N-メチル-9H-プリン-6-アミン ChemComp-OYK: ~{N},9-dimethylpurin-6-amine / 9,N-ジメチル-9H-プリン-6-アミン ChemComp-OYT: 9-cyclopropyl-~{N}-methyl-purin-6-amine ChemComp-5ZK: ~{N},3-dimethyl-1~{H}-pyrazolo[4,3-d]pyrimidin-7-amine ChemComp-7RN: N-methyl-3-(5-methylthiophen-2-yl)-1H-pyrazole-5-carboxamide ChemComp-7RT: N-methyl-1H-indole-4-carboxamide ChemComp-7RI: 5-bromanyl-N-methyl-1H-indazole-3-carboxamide ChemComp-7RE: 6-methyl-3H-pyridin-2-one ChemComp-GOL: GLYCEROL / グリセロ-ル ChemComp-7RX: (R)-homoproline ChemComp-7SL: 5-(furan-2-yl)-N-methyl-1H-pyrazole-3-carboxamide ChemComp-OWH: ~{N}-methylpyridine-3-carbothioamide
由来	homo sapiens (ヒト)
キーワード	RNA BINDING PROTEIN / YTHDC1 / m6A / complex / inhibitor