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Structure paper

Title: Identification of an allosteric site on the E3 ligase adapter cereblon.
Journal, issue, pagesTo Be Published
Publish dateAug 19, 2025 (structure data deposition date)
AuthorsChung, C.
External linksSearch PubMed
MethodsX-ray diffraction
Resolution2.39 Å
Structure data

PDB-9sfm:
Crystal structure of Cereblon-DDB1 in complex with SB-405483 and Lenalidomide
Method: X-RAY DIFFRACTION / Resolution: 2.39 Å

Chemicals

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-ZN:
Unknown entry

ChemComp-LVY:
S-Lenalidomide

PDB-1ceg:
CEPHALOTHIN COMPLEXED WITH DD-PEPTIDASE

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsLIGASE / E3 ubiquitin ligase / substrate receptor / IMiDs (immunomodulatory drugs) / Allosteric modulator

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