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TitleCovalent alkynylpyridopyrimidinones targeting cysteine 775 of the epidermal growth factor receptor overcome resistance to current therapies
Journal, issue, pagesTo Be Published
Publish dateOct 17, 2024 (structure data deposition date)
AuthorsStewart, H.L. / Waring, M.J.
External linksSearch PubMed
MethodsX-ray diffraction
Resolution3.163 Å
Structure data

PDB-9h46:
EGFR wild type in complex with 25328
Method: X-RAY DIFFRACTION / Resolution: 3.163 Å

Chemicals

PDB-1isa:
STRUCTURE-FUNCTION IN E. COLI IRON SUPEROXIDE DISMUTASE: COMPARISONS WITH THE MANGANESE ENZYME FROM T. THERMOPHILUS

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / KINASE / EGFR / INHIBITOR

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