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TitleCryo-EM structures and binding of mouse and human ACE2 to SARS-CoV-2 variants of concern indicate that mutations enabling immune escape could expand host range
Journal, issue, pagesPlos Pathog., Year 2023
Publish dateAug 5, 2022 (structure data deposition date)
AuthorsNi D / Turelli P / Beckert B / Nazarov S / Uchikawa E / Myasnikov A / Pojer F / Trono D / Stahlberg H / Lau K
External linksPlos Pathog. / Search PubMed
MethodsEM (single particle)
Resolution2.89 - 4.4 Å
Structure data

EMDB-15541: Beta SARS-CoV-2 Spike bound to mouse ACE2 (two up, full)
Method: EM (single particle) / Resolution: 4.4 Å

EMDB-15580: BA.1 SARS-CoV-2 Spike bound to mouse ACE2 (two up, full)
Method: EM (single particle) / Resolution: 3.22 Å

EMDB-15581: BA.1 SARS-CoV-2 Spike bound to mouse ACE2 (three up, full)
Method: EM (single particle) / Resolution: 3.03 Å

EMDB-15584: BA.2.12.1 SARS-CoV-2 Spike bound to mouse ACE2 (two up, full)
Method: EM (single particle) / Resolution: 3.03 Å

EMDB-15585: BA.2.12.1 SARS-CoV-2 Spike bound to mouse ACE2 (three up, full)
Method: EM (single particle) / Resolution: 2.89 Å

EMDB-15586: BA.4/5 SARS-CoV-2 Spike bound to mouse ACE2 (two up, full)
Method: EM (single particle) / Resolution: 2.92 Å

EMDB-15587: BA.4/5 SARS-CoV-2 Spike bound to human ACE2 (three up, full)
Method: EM (single particle) / Resolution: 2.92 Å

EMDB-15592: BA.4/5 SARS-CoV-2 Spike bound to mouse ACE2 (local)
Method: EM (single particle) / Resolution: 3.3 Å

Source
  • Severe acute respiratory syndrome coronavirus 2
  • Mus musculus (house mouse)
  • Homo sapiens (human)
  • Tequatrovirus T4

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