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Structure paper

TitleDevelopment of clinically viable nonmuscle myosin II small molecule inhibitors
Journal, issue, pagesTo Be Published
Publish dateJun 26, 2024 (structure data deposition date)
AuthorsRadnai, L. / Young, E.J. / Kikuti, C.M. / Hafenbreidel, M. / Stremel, R. / Lin, L. / Toth, K. / Pasetto, P. / Jin, X. / Geedy, M. ...Radnai, L. / Young, E.J. / Kikuti, C.M. / Hafenbreidel, M. / Stremel, R. / Lin, L. / Toth, K. / Pasetto, P. / Jin, X. / Geedy, M. / Partridge, J. / Patel, A. / Conlon, M. / Briggs, S. / Sweeney, L.H. / Sellers, J. / Krieger-Burke, T. / Rumbaugh, G. / Cameron, M.D. / Surman, M. / Houdusse-Juille, A. / Griffin, P.R. / Kamenecka, T.M. / Miller, C.A.
External linksSearch PubMed
MethodsX-ray diffraction
Resolution2.581 Å
Structure data

PDB-9fu2:
Smooth Muscle Myosin II in complex with MT-228
Method: X-RAY DIFFRACTION / Resolution: 2.581 Å

Chemicals

ChemComp-ADP:
ADENOSINE-5'-DIPHOSPHATE / ADP, energy-carrying molecule*YM

ChemComp-VO4:
VANADATE ION

ChemComp-MG:
Unknown entry

ChemComp-DMS:
DIMETHYL SULFOXIDE / DMSO, precipitant*YM

ChemComp-EDO:
1,2-ETHANEDIOL

PDB-1ige:
Unknown entry

ChemComp-CL:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsMOTOR PROTEIN / Smooth Muscle Myosin II;MT-228;myosin modulator;addiction;therapy;drug design

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