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TitleHuman Adenylosuccinate Lyase in Complex with its Substrate N6-(1,2-Dicarboxyethyl)-AMP, and its Products AMP and Fumarate.
Journal, issue, pagesTo be Published
Publish dateSep 30, 2007 (structure data deposition date)
AuthorsStenmark, P. / Moche, M. / Arrowsmith, C. / Berglund, H. / Busam, R. / Collins, R. / Dahlgren, L.G. / Edwards, A. / Flodin, S. / Flores, A. ...Stenmark, P. / Moche, M. / Arrowsmith, C. / Berglund, H. / Busam, R. / Collins, R. / Dahlgren, L.G. / Edwards, A. / Flodin, S. / Flores, A. / Graslund, S. / Hammarstrom, M. / Hallberg, B.M. / Holmberg-Schiavone, L. / Johansson, I. / Kallas, A. / Karlberg, T. / Kotenyova, T. / Lehtio, L. / Nilsson, M. / Nyman, T. / Ogg, D. / Persson, C. / Sagemark, J. / Sundstrom, M. / Thorsell, A.G. / Tresaugues, L. / Van Den Berg, S. / Weigelt, J. / Welin, M. / Nordlund, P.
External linksSearch PubMed
MethodsX-ray diffraction
Resolution2 Å
Structure data

PDB-2vd6:
Human adenylosuccinate lyase in complex with its substrate N6-(1,2- Dicarboxyethyl)-AMP, and its products AMP and fumarate.
Method: X-RAY DIFFRACTION / Resolution: 2 Å

Chemicals

ChemComp-AMP:
ADENOSINE MONOPHOSPHATE / AMP*YM

ChemComp-FUM:
FUMARIC ACID

ChemComp-GOL:
GLYCEROL

ChemComp-CL:
Unknown entry

ChemComp-2SA:
2-[9-(3,4-DIHYDROXY-5-PHOSPHONOOXYMETHYL-TETRAHYDRO-FURAN-2-YL)-9H-PURIN-6-YLAMINO]-SUCCINIC ACID

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsLYASE / PURINE BIOSYNTHESIS / EPILEPSY / PURINE METABOLISM

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