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TitleRational Design of PI3K-alpha Inhibitors that Exhibit Selectivity Over the PI3K-beta Isoform
Journal, issue, pagesTo be Published
Publish dateAug 1, 2011 (structure data deposition date)
AuthorsHeffron, T. / Wei, B. / Olivero, A.G. / Staben, S.T. / Tsui, V. / Do, S. / Dotson, J. / Folkes, A. / Goldsmith, A. / Goldsmith, R. ...Heffron, T. / Wei, B. / Olivero, A.G. / Staben, S.T. / Tsui, V. / Do, S. / Dotson, J. / Folkes, A. / Goldsmith, A. / Goldsmith, R. / Gunzner, J. / Lesnick, J. / Lewis, C. / Mathieu, S. / Nonomiya, J. / Sutherlin, D.P. / Wan, N.C. / Wang, S. / Weismann, C. / Zhu, B.
External linksSearch PubMed
MethodsX-ray diffraction
Resolution2.5 Å
Structure data

PDB-3t8m:
Rational Design of PI3K-alpha Inhibitors that Exhibit Selectivity Over the PI3K-beta Isoform
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

Chemicals

ChemComp-3T8:
N~2~-{2-chloro-4-[(4-methylpiperazin-1-yl)carbonyl]phenyl}-N~2~,N~8~-dimethyl-4,5-dihydrothieno[3,2-d][1]benzoxepine-2,8-dicarboxamide

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE/TRANSFERASE INHIBITOR / kinase p110 / TRANSFERASE-TRANSFERASE INHIBITOR complex

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