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TitleLong Residence Time Inhibitors of Dihydrofolate Reductase Display Potent Activity Against Mycobacterium Avium.
Journal, issue, pagesTo Be Published
Publish dateJan 26, 2024 (structure data deposition date)
AuthorsWright, L. / Krucinska, J. / Erlandsen, H. / Haijan, B. / Cynamon, M. / Wright, D.
External linksSearch PubMed
MethodsX-ray diffraction
Resolution2 Å
Structure data

PDB-8vtc:
Crystal structure of Mycobacterium avium dihydrofolate reductase in complex with NADPH and trimethoprim
Method: X-RAY DIFFRACTION / Resolution: 2 Å

Chemicals

ChemComp-NDP:
NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE

ChemComp-TOP:
TRIMETHOPRIM / antibiotic*YM

ChemComp-CL:
Unknown entry

ChemComp-HOH:
WATER

Source
  • mycobacterium avium (bacteria)
KeywordsOXIDOREDUCTASE/INHIBITOR / dihydrofolate reductase / Mycobacterium avium / trimetoprim / OXIDOREDUCTASE / OXIDOREDUCTASE-INHIBITOR complex

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