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TitleCryo-EM structure of the alpha1beta3 GABA(A) receptor in complex with GABA and Mb25 in the short-lived symmetric pre-active state
Journal, issue, pagesTo Be Published
Publish dateMay 23, 2024 (structure data deposition date)
AuthorsMihaylov DB / Malinauskas T / Aricescu AR
External linksSearch PubMed
MethodsEM (single particle)
Resolution2.8 Å
Structure data

50365

9ffl

EMDB-50365, PDB-9ffl:
Cryo-EM structure of the alpha1beta3 GABA(A) receptor in complex with GABA and Mb25 in the short-lived symmetric bound-closed state
Method: EM (single particle) / Resolution: 2.8 Å

Chemicals

ChemComp-D10:
DECANE

ChemComp-POV:
(2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate / phospholipid*YM

ChemComp-CL:
Unknown entry

ChemComp-ABU:
GAMMA-AMINO-BUTANOIC ACID

ChemComp-R16:
HEXADECANE

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • lama glama (llama)
  • helicobacter pylori g27 (bacteria)
KeywordsMEMBRANE PROTEIN / GABA / neurotransmission / gating cycle / time-resolved cryo-EM

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