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Structure paper

TitleTowards New Anti-Influenza Therapeutics: Structure-Activity Relationships in the Interaction between Heterotrimeric Influenza Polymerase and Pol II C-terminal domain
Journal, issue, pagesTo Be Published
Publish dateJan 14, 2018 (structure data deposition date)
AuthorsClaron, M. / Lukarska, M. / Uhrig, U. / Sehr, P. / Drncova, P. / Lewis, J.D. / Will, D.W. / Cusack, S.
External linksSearch PubMed
MethodsX-ray diffraction
Resolution2.7 - 2.8 Å
Structure data

PDB-6fhh:
Crystal structure of bat influenza A/H17N10 polymerase with viral RNA promoter bound to a 22-mer modified Pol II CTD peptide with serine 5 thiophosphorylated.
Method: X-RAY DIFFRACTION / Resolution: 2.7 Å

PDB-6fhi:
Crystal structure of bat influenza A/H17N10 polymerase with viral RNA promoter bound to a 19-mer serine 5 phosphorylated Pol II CTD peptide with a truncated linker.
Method: X-RAY DIFFRACTION / Resolution: 2.8 Å

Chemicals

ChemComp-PO4:
PHOSPHATE ION

ChemComp-ZN:
Unknown entry

ChemComp-HOH:
WATER

Source
  • influenza a virus (a/little yellow-shouldered bat/guatemala/060/2010(h17n10))
  • influenza a virus
  • homo sapiens (human)
KeywordsVIRAL PROTEIN / Influenza virus / RNA-dependent RNA polymerase / modified Pol II CTD peptide

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