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TitleCRYSTAL STRUCTURE OF THE HUMAN PRMT5:MEP50 COMPLEX with JNJB44355437
Journal, issue, pagesTo Be Published
Publish dateJan 24, 2021 (structure data deposition date)
AuthorsBrown, D. / Robinson, C. / Carr, K.H. / Pande, V.
External linksSearch PubMed
MethodsX-ray diffraction
Resolution2.83 Å
Structure data

PDB-7bo7:
CRYSTAL STRUCTURE OF THE HUMAN PRMT5:MEP50 COMPLEX with JNJB44355437
Method: X-RAY DIFFRACTION / Resolution: 2.83 Å

Chemicals

ChemComp-U6K:
(2~{R},3~{R},4~{S},5~{R})-2-[(4~{a}~{S},7~{a}~{S})-4-azanyl-1,4,4~{a},7~{a}-tetrahydropyrrolo[2,3-d]pyrimidin-7-yl]-5-(quinolin-7-yloxymethyl)oxolane-3,4-diol

ChemComp-EPE:
4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID / pH buffer*YM

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-PEG:
DI(HYDROXYETHYL)ETHER

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSLOCASE / complex inhibitor bound PRMT5 MEP50

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