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Title | Human prostaglandin/alkenal reductases: substrate specificities, inhibitor profiles, structural insights and subcellular localization suggest protective roles in inflammatory and oxidative stress conditions. |
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Journal, issue, pages | To Be Published |
Publish date | Mar 31, 2022 (structure data deposition date) |
![]() | Shafqat, N. / Dakin, S.G. / Estrada, F.M. / Niesen, F.H. / Wells, G. / Yapp, C. / Troumpra, M.K. / Brotherton, D. / Porte, S. / Mesa, J. ...Shafqat, N. / Dakin, S.G. / Estrada, F.M. / Niesen, F.H. / Wells, G. / Yapp, C. / Troumpra, M.K. / Brotherton, D. / Porte, S. / Mesa, J. / Yakovtseva, E. / Farres, J. / Pares, X. / Liu, T. / Altman, R. / Carr, A. / Koekemoer, L. / Niesen, F. / Yue, W.W. / Opperman, U. |
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Methods | X-ray diffraction |
Resolution | 1.79 Å |
Structure data | ![]() PDB-7zej: |
Chemicals | ![]() ChemComp-NAP: ![]() ChemComp-CEL: ![]() ChemComp-HOH: |
Source |
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![]() | OXIDOREDUCTASE / alkenal reductases / prostaglandin reductases / phase 1 xenobiotic metabolism / reactive oxygen species / lipid peroxidation / polyunsaturated fatty acid / inflammation / lipid mediator metabolism / Structural Genomics / Structural Genomics Consortium / SGC |