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TitleA straightforward approach to antibodies recognising cancer specific glycopeptidic neoepitopes
Journal, issue, pagesChem Sci, Vol. 11, Page 4999-5006, Year 2020
Publish dateSep 9, 2019 (structure data deposition date)
AuthorsWakui, H. / Tanaka, Y. / Ose, T. / Matsumoto, I. / Kato, K. / Min, Y. / Tachibana, T. / Sato, M. / Naruchi, K. / Martin, F.G. ...Wakui, H. / Tanaka, Y. / Ose, T. / Matsumoto, I. / Kato, K. / Min, Y. / Tachibana, T. / Sato, M. / Naruchi, K. / Martin, F.G. / Hinou, H. / Nishimura, S.-I.
External linksChem Sci / Search PubMed
MethodsX-ray diffraction
Resolution1.773 - 2.404 Å
Structure data

PDB-6kx0:
Crystal structure of SN-101 mAb non-liganded form
Method: X-RAY DIFFRACTION / Resolution: 2.404 Å

PDB-6kx1:
Crystal structure of SN-101 mAb in complex with MUC1 glycopeptide
Method: X-RAY DIFFRACTION / Resolution: 1.773 Å

Chemicals

ChemComp-TRS:
2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL / pH buffer*YM

ChemComp-HOH:
WATER

ChemComp-A2G:
2-acetamido-2-deoxy-alpha-D-galactopyranose

Source
  • mus musculus (house mouse)
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / Antibody / IgG1 / MUC1 / Glycopeptide

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