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Structure paper

TitleClearing the Path to Rapid High-Quality Protein Purification
Journal, issue, pagesTo Be Published
Publish dateOct 11, 2021 (structure data deposition date)
AuthorsChen, X. / Wendorff, T. / Jao, C. / Kung, J.E. / Liau, N.P.D. / Wu, P. / Yu, C. / Oh, A. / Boenig, G. / Wallweber, H. ...Chen, X. / Wendorff, T. / Jao, C. / Kung, J.E. / Liau, N.P.D. / Wu, P. / Yu, C. / Oh, A. / Boenig, G. / Wallweber, H. / Everett, C. / Miu, A. / Brillantes, B. / Mortara, K. / Murray, J. / Koth, C.M. / Sudhamsu, J.
External linksSearch PubMed
MethodsX-ray diffraction
Resolution1.6 - 2.88 Å
Structure data

PDB-7shv:
Crystal structure of BRAF kinase domain bound to GDC0879
Method: X-RAY DIFFRACTION / Resolution: 2.88 Å

PDB-7si1:
Crystal structure of apo EGFR kinase domain
Method: X-RAY DIFFRACTION / Resolution: 1.6 Å

Chemicals

ChemComp-29L:
2-{4-[(1E)-1-(hydroxyimino)-2,3-dihydro-1H-inden-5-yl]-3-(pyridin-4-yl)-1H-pyrazol-1-yl}ethanol

ChemComp-CL:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-MES:
2-(N-MORPHOLINO)-ETHANESULFONIC ACID / pH buffer*YM

ChemComp-SO4:
SULFATE ION

Source
  • homo sapiens (human)
KeywordsTRANSFERASE/TRANSFERASE inhibitor / kinase / kinase inhibitor / TRANSFERASE / TRANSFERASE-TRANSFERASE inhibitor complex / receptor tyrosine kinase

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