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Structure paper

TitleInactivation of RhoA for hypertension treatment through a TRPV4-RhoA-RhoGDI1 axis
Journal, issue, pagesTo Be Published
Publish dateJul 13, 2024 (structure data deposition date)
AuthorsWang JW / Yuan Z
External linksSearch PubMed
MethodsEM (single particle)
Resolution3.16 - 3.37 Å
Structure data

60797

9iqx

EMDB-60797, PDB-9iqx:
Cryo-EM structure of the human TRPV4-RhoA in complex with AH001
Method: EM (single particle) / Resolution: 3.37 Å

60798

9iqy

EMDB-60798, PDB-9iqy:
Cryo-EM structure of human TRPV4 intracellular domain in complex with GTPase RhoA
Method: EM (single particle) / Resolution: 3.16 Å

Chemicals

ChemComp-P5S:
O-[(R)-{[(2R)-2,3-bis(octadecanoyloxy)propyl]oxy}(hydroxy)phosphoryl]-L-serine


ChemComp, No image

ChemComp-U6L:
Unknown entry

ChemComp-GDP:
GUANOSINE-5'-DIPHOSPHATE / GDP, energy-carrying molecule*YM

ChemComp-MG:
Unknown entry

Source
  • homo sapiens (human)
KeywordsMEMBRANE PROTEIN / Antagonist / Complex / Hydrolase

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