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| Title | Discovery of Lenacapavir: First-in-Class Twice-Yearly Capsid Inhibitor for HIV-1 Treatment and Pre-exposure Prophylaxis |
|---|---|
| Journal, issue, pages | J. Med. Chem., Year 2025 |
| Publish date | Jul 8, 2025 (structure data deposition date) |
 Authors | Canales, E. / Tse, W. / Schroeder, S.D. / Chou, C.H. / Liu, Q. / Zhang, J. / Lazerwith, S.E. / Morganelli, P. / Saito, R.D. / Brizgys, G. ...Canales, E. / Tse, W. / Schroeder, S.D. / Chou, C.H. / Liu, Q. / Zhang, J. / Lazerwith, S.E. / Morganelli, P. / Saito, R.D. / Brizgys, G. / Li, J. / Wu, Q. / Graupe, M. / Halcomb, R.L. / Desai, M. / Cannizzaro, C. / Hu, E. / Perry, J.K. / Villasenor, A.G. / Somoza, J.R. / Ferrao, R.D. / Swaminathan, S. / Zheng, J. / Lu, B. / Mwangi, J. / Wang, K. / Subramanian, R. / Smith, B.J. / Rhodes, G. / Rowe, W. / Sauer, D. / Lad, L. / Papalia, G.A. / Clancy, S. / Stepan, G.J. / Yu, H. / Sakowicz, R. / Shi, B. / Carr, G. / Bam, R.A. / Tsai, L.K. / Singer, E. / Hansen, D. / Mulato, A. / Yant, S.R. / Cihlar, T. / Link, J.O. |
 External links | J. Med. Chem. / Search PubMed |
| Methods | X-ray diffraction |
| Resolution | 2.2 - 3.36 Å |
| Structure data |  PDB-9pgs:  PDB-9pgt:  PDB-9pgu:  PDB-9pgv: |
| Chemicals |  PDB-1ch4:  ChemComp-HOH:  PDB-1ch5: 
PDB-1ch6: Unknown entry  PDB-1ch7: |
| Source |
|
 Keywords | VIRAL PROTEIN / Capsid / p24 / HIV-1 |
human immunodeficiency virus 1