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TitleAbstract 4451: Evaluation of the therapeutic potential of phosphine oxide pyrazole inhibitors in tumors harboring EGFR C797S mutation
Journal, issue, pagesCancer Res., Vol. 79, Page 4451-, Year 2019
Publish dateSep 17, 2020 (structure data deposition date)
AuthorsFloch, N. / Finlay, M.R.V. / Bianco, A. / Bickerton, S. / Colclough, N. / Cross, D.A. / Cuomo, E.M. / Guerot, C.M. / Hargreaves, D. / Martin, M.J. ...Floch, N. / Finlay, M.R.V. / Bianco, A. / Bickerton, S. / Colclough, N. / Cross, D.A. / Cuomo, E.M. / Guerot, C.M. / Hargreaves, D. / Martin, M.J. / McKerrecher, D. / O'Neill, D.J. / Orme, J.P. / Rahi, A. / Smith, P.D. / Ward, R.A.
External linksCancer Res. / Search PubMed
MethodsX-ray diffraction
Resolution2.65 Å
Structure data

PDB-7aei:
Studies Towards a Reversible EGFR C797S Triple Mutant Inhibitor Series
Method: X-RAY DIFFRACTION / Resolution: 2.65 Å

PDB-7aem:
Studies Towards a Reversible EGFR C797S Triple Mutant Inhibitor Series
Method: X-RAY DIFFRACTION / Resolution: 2.65 Å

Chemicals

ChemComp-R85:
5-chloranyl-~{N}2-[4-[4-(dimethylamino)piperidin-1-yl]-2-methoxy-5-(1-methylpyrazol-4-yl)phenyl]-~{N}4-(2-dimethylphosphorylphenyl)pyrimidine-2,4-diamine

ChemComp-HOH:
WATER

ChemComp-6GY:
5-chloro-N~4~-[2-(dimethylphosphoryl)phenyl]-N~2~-{2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}pyrimidine-2,4-diamine / inhibitor*YM

Source
  • homo sapiens (human)
KeywordsCELL CYCLE / EGFR

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