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TitleDe novo mimetic protein of interleukin-21 shows outstanding therapeutic efficacy in cancer.
Journal, issue, pagesTo Be Published
Publish dateOct 22, 2024 (structure data deposition date)
AuthorsChun, J.H. / Zhangxu, K. / Roy, S. / Abhiraman, G.C. / Garcia, K.C. / Dougan, S.K. / Leonard, W. / Dougan, M. / Baker, D.
External linksSearch PubMed
MethodsX-ray diffraction
Resolution2.28 Å
Structure data

PDB-9e2t:
Structure of a de novo designed interleukin-21 mimetic complex with IL-21R and IL-2Rg
Method: X-RAY DIFFRACTION / Resolution: 2.28 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-HOH:
WATER

Source
  • synthetic construct (others)
  • homo sapiens (human)
KeywordsDE NOVO PROTEIN/IMMUNE SYSTEM / cytokine / immunology / interleukin / DE NOVO PROTEIN / DE NOVO PROTEIN-IMMUNE SYSTEM complex

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