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Structure paper

TitleDevelopment of AB8939, a Novel Colchicine-like Microtubule Synthetic Destabilizer with the Ability to Overcome Multidrug Resistance
Journal, issue, pagesTO BE PUBLISHED
Publish dateFeb 6, 2023 (structure data deposition date)
AuthorsHumbert, M. / Letard, S. / Neves, M. / Siavoshian Jeay, S. / Goubard, A. / Casteran, N. / Rebuffet, E. / Hajem, B. / Gros, L. / Varela, P.F. ...Humbert, M. / Letard, S. / Neves, M. / Siavoshian Jeay, S. / Goubard, A. / Casteran, N. / Rebuffet, E. / Hajem, B. / Gros, L. / Varela, P.F. / Gigant, B. / Verdier, P. / Castellano, R. / Colette, Y. / Vey, N. / Pez, D. / Benjahad, A. / Moussy, A. / Mansfield, C. / Dubreuil, P.
External linksSearch PubMed
MethodsX-ray diffraction
Resolution2.527 Å
Structure data

PDB-8cgz:
tubulin-AB8939 complex
Method: X-RAY DIFFRACTION / Resolution: 2.527 Å

Chemicals

ChemComp-GTP:
GUANOSINE-5'-TRIPHOSPHATE / GTP, energy-carrying molecule*YM

ChemComp-MG:
Unknown entry

ChemComp-GDP:
GUANOSINE-5'-DIPHOSPHATE / GDP, energy-carrying molecule*YM


ChemComp, No image

ChemComp-UIY:
Unknown entry

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

Source
  • rattus norvegicus (Norway rat)
  • ovis aries (sheep)
KeywordsCELL CYCLE / MICROTUBULE DYNAMICS / INHIBITOR / CYTOSKELETON / CELL DIVISION

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