| Title | Structural Basis for Target Discrimination and Activation by Cas13d |
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| Journal, issue, pages | To Be Published |
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| Publish date | Nov 13, 2024 (structure data deposition date) |
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Authors | Chou CW / Finkelstein IJ |
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External links | Search PubMed |
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| Methods | EM (single particle) |
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| Resolution | 3.01 - 3.47 Å |
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| Structure data | EMDB-47892, PDB-9ebu: Wild-type EsCas13d binary complex Method: EM (single particle) / Resolution: 3.06 Å EMDB-47903, PDB-9ec9: Intermediate state of wild-type EsCas13d ternary complex Method: EM (single particle) / Resolution: 3.26 Å EMDB-47904, PDB-9eca: Intermediate state of wild-type EsCas13d ternary complex with C4A mismatch Method: EM (single particle) / Resolution: 3.19 Å EMDB-47905, PDB-9ecb: Intermediate state of wild-type EsCas13d ternary complex with U10G mismatch Method: EM (single particle) / Resolution: 3.15 Å EMDB-47906, PDB-9ecc: Inactive state of wild-type EsCas13d ternary complex with U10G mismatch Method: EM (single particle) / Resolution: 3.32 Å EMDB-47907, PDB-9ecd: Active state of wild-type EsCas13d ternary complex with U10G mismatch Method: EM (single particle) / Resolution: 3.47 Å EMDB-47908, PDB-9ece: Inactive state of wild-type EsCas13d ternary complex with C4A mismatch Method: EM (single particle) / Resolution: 3.01 Å |
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| Chemicals | |
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| Source | [eubacterium] siraeum dsm 15702 (bacteria)
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Keywords | RNA BINDING PROTEIN/RNA / Cas13 / CRISPR / HEPN / RNA nuclease / RNA BINDING PROTEIN-RNA complex |
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