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Structure paper

TitleIn silico design of stable single-domain antibodies against multiple targets.
Journal, issue, pagesTo be published
Publish dateApr 12, 2024 (structure data deposition date)
Authorsvan der Kant, R. / Zhang, Z. / Markovic, I. / Vizarraga, D. / Garcia, T. / Maragkou, K. / Delgado, J. / Cianferoni, D. / Orlando, G. / Carolis, C. ...van der Kant, R. / Zhang, Z. / Markovic, I. / Vizarraga, D. / Garcia, T. / Maragkou, K. / Delgado, J. / Cianferoni, D. / Orlando, G. / Carolis, C. / Savvides, S. / N.Volkov, A. / Dewilde, M. / Schymkowitz, J. / Serrano, L. / Rousseau, F.
External linksSearch PubMed
MethodsX-ray diffraction
Resolution1.94 - 1.97 Å
Structure data

PDB-9ezh:
Structure of single-domain antibody VHH_h4 in complex with human Vsig4
Method: X-RAY DIFFRACTION / Resolution: 1.94 Å

PDB-9ezi:
Structure of single-domain antibody VHH_h5 in complex with human Vsig4
Method: X-RAY DIFFRACTION / Resolution: 1.97 Å

Chemicals

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • camelidae (mammal)
KeywordsIMMUNE SYSTEM / Nanobody / Mutations / CDR2 / CDR3 / hVsig4 / B7 family / immune regulatory proteins

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