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Structure paper

TitleStructural study of human glutamate transporter EAAT2
Journal, issue, pagesDian Zi Xian Wei Xue Bao, Year 2025
Publish dateOct 9, 2024 (structure data deposition date)
AuthorsXia LY / Zhang YY / Shi Y / Huang J / Zhou Q
External linksSearch PubMed
MethodsEM (single particle)
Resolution2.82 - 3.97 Å
Structure data

61844

9jvv

EMDB-61844, PDB-9jvv:
Overall structure of human EAAT2 in the substrate-free state
Method: EM (single particle) / Resolution: 2.82 Å

61845

9jvw

EMDB-61845, PDB-9jvw:
Overall structure of human EAAT2 bound with inhibitor (WAY-213613)
Method: EM (single particle) / Resolution: 3.41 Å

61846

9jvx

EMDB-61846, PDB-9jvx:
Overall structure of human EAAT2 bound with activator (GT949)
Method: EM (single particle) / Resolution: 3.97 Å

Chemicals

ChemComp-CLR:
CHOLESTEROL

ChemComp-GJ0:
(2S)-2-azanyl-4-[[4-[2-bromanyl-4,5-bis(fluoranyl)phenoxy]phenyl]amino]-4-oxidanylidene-butanoic acid / inhibitor*YM

ChemComp-3PH:
1,2-DIACYL-GLYCEROL-3-SN-PHOSPHATE

PDB-1edj:
STAPHYLOCOCCAL PROTEIN A E-DOMAIN (180), NMR, 20 STRUCTURES

Source
  • homo sapiens (human)
KeywordsTRANSPORT PROTEIN / transporter

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