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TitleHigh-resolution crystal structure of human JAK2 kinase domain (JH1) bound to PN5-150.
Journal, issue, pagesTo Be Published
Publish dateFeb 3, 2021 (structure data deposition date)
AuthorsKarim, M.R. / Schonbrunn, E.
External linksSearch PubMed
MethodsX-ray diffraction
Resolution1.5 Å
Structure data

PDB-7ll5:
High-resolution crystal structure of human JAK2 kinase domain (JH1) bound to PN5-150.
Method: X-RAY DIFFRACTION / Resolution: 1.5 Å

Chemicals

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-Y5G:
{1-(ethylsulfonyl)-3-[4-(2-{[4-(1-methylpiperidin-4-yl)phenyl]amino}-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]azetidin-3-yl}acetonitrile

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / rheumatoid arthritis / innate immuninity / adaptive immunity / myeloproliferative neoplasms

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