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Structure paper

TitleCrystal structure of BRD2 second bromodomain in complex with a 3,5-dimethylisoxazol ligand
Journal, issue, pagesTo Be Published
Publish dateJun 2, 2015 (structure data deposition date)
AuthorsTallant, C. / Hay, D. / Krojer, T. / Nunez-Alonso, G. / Picaud, S. / Newman, J.A. / Fedorov, O. / von Delft, F. / Arrowsmith, C.H. / Edwards, A.M. ...Tallant, C. / Hay, D. / Krojer, T. / Nunez-Alonso, G. / Picaud, S. / Newman, J.A. / Fedorov, O. / von Delft, F. / Arrowsmith, C.H. / Edwards, A.M. / Bountra, C. / Brennan, P.E. / Knapp, S.
External linksSearch PubMed
MethodsX-ray diffraction
Resolution1.4 Å
Structure data

PDB-5bt5:
Crystal structure of BRD2 second bromodomain in complex with SGC-CBP30 chemical probe
Method: X-RAY DIFFRACTION / Resolution: 1.4 Å

Chemicals

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-2LO:
2-[2-(3-chloro-4-methoxyphenyl)ethyl]-5-(3,5-dimethyl-1,2-oxazol-4-yl)-1-[(2S)-2-(morpholin-4-yl)propyl]-1H-benzimidazole

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSCRIPTION / chromatin and transcription regulator / acetylation / Structural Genomics / Structural Genomics Consortium / SGC

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