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Structure paper

TitleStructural basis of cis- and trans-combretastatin binding to tubulin
Journal, issue, pagesChem, Year 2017
Publish dateSep 28, 2016 (structure data deposition date)
AuthorsGaspari, R. / Prota, A.E. / Bargsten, K. / Cavalli, A. / Steinmetz, M.O.
External linksChem / Search PubMed
MethodsX-ray diffraction
Resolution2.397 Å
Structure data

PDB-5lyj:
Tubulin-Combretastatin A4 complex
Method: X-RAY DIFFRACTION / Resolution: 2.397 Å

Chemicals

ChemComp-GTP:
GUANOSINE-5'-TRIPHOSPHATE / GTP, energy-carrying molecule*YM

ChemComp-MG:
Unknown entry

ChemComp-CA:
Unknown entry

ChemComp-GOL:
GLYCEROL

ChemComp-GDP:
GUANOSINE-5'-DIPHOSPHATE / GDP, energy-carrying molecule*YM

ChemComp-7BA:
Combretastatin A4

ChemComp-MES:
2-(N-MORPHOLINO)-ETHANESULFONIC ACID / pH buffer*YM

ChemComp-ACP:
PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER / AMP-PCP, energy-carrying molecule analogue*YM

ChemComp-HOH:
WATER

Source
  • rattus norvegicus (Norway rat)
  • gallus gallus (chicken)
  • bos taurus (domestic cattle)
KeywordsCELL CYCLE / TUBULIN FOLD / CYTOSKELETON / CELL CYCLE- INHIBITOR COMPLEX

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