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TitleA cooperative binding mechanism steers the recruitment of peripheral subunits in the E. coli pyruvate dehydrogenase complex
Journal, issue, pagesTo Be Published
Publish dateOct 9, 2024 (structure data deposition date)
AuthorsBothe, S.N. / Racunica, D. / Zajec Hudnik, T. / Zdanowicz, R. / Bothe, A. / Giese, C. / Glockshuber, R.
External linksSearch PubMed
MethodsX-ray diffraction
Resolution1.54 - 1.97 Å
Structure data

PDB-9h1n:
Dihydrolipoamide Acetyltransferase (E2) PSBD in complex with the Pyruvate Dehydrogenase (E1) binding domain from E. coli
Method: X-RAY DIFFRACTION / Resolution: 1.54 Å

PDB-9h2i:
Dihydrolipoyl Dehydrogenase (E3) in complex with the binding domain of Dihydrolipoamide Acetyltransferase (E2) from the E. coli pyruvate dehydrogenase complex
Method: X-RAY DIFFRACTION / Resolution: 1.97 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-FAD:
FLAVIN-ADENINE DINUCLEOTIDE / FAD*YM

Source
  • escherichia coli (E. coli)
KeywordsPROTEIN BINDING / Complex / pyruvate dehydrogenase / OXIDOREDUCTASE / FLAVOPROTEIN / electrostatic binding

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