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TitleTriptolide sensitizes cancer cells to nucleoside DNA methyltransferase inhibitors through inhibition of DCTPP1 mediated cell-intrinsic resistance
Journal, issue, pagesTo Be Published
Publish dateMay 14, 2021 (structure data deposition date)
AuthorsLiu, J. / He, Q.-L. / Zhou, J. / Chikarmane, R.V. / Hauk, G. / Rachakonda, A. / Vaghasia, A.M. / Castagna, N. / Steinberg, R.C. / Anders, N.M. ...Liu, J. / He, Q.-L. / Zhou, J. / Chikarmane, R.V. / Hauk, G. / Rachakonda, A. / Vaghasia, A.M. / Castagna, N. / Steinberg, R.C. / Anders, N.M. / Wanjiku, T.M. / Nuhn, P. / Shim, J.S. / Giovinazzo, H. / Esopi, D.M. / Kim, K. / Coulter, J. / Wang, R. / Rudek, M.A. / Berger, J.M. / Liu, J.O. / Nelson, W.G. / Yegnasubramanian, S.
External linksSearch PubMed
MethodsX-ray diffraction
Resolution2.2 Å
Structure data

PDB-7mu5:
Human DCTPP1 bound to Triptolide
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

Chemicals

ChemComp-MG:
Unknown entry

ChemComp-TLI:
triptolide

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHYDROLASE/INHIBITOR / Inhibitor / pyrophosphatase / HYDROLASE / HYDROLASE-INHIBITOR complex

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