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TitleStructural and in Vitro Chracterization of Pridyl Derivatives of Benzaldehydes: Highly Potent Antisickling Agents
Journal, issue, pagesTo be Published
Publish dateJul 17, 2009 (structure data deposition date)
AuthorsOsheiza, A. / Mohini, G. / Ijoema, N. / Amit, K.G. / Faik, N.M. / Richmond, D.-D. / Toshio, A. / Martin, K.S.
External linksSearch PubMed
MethodsX-ray diffraction
Resolution1.8 Å
Structure data

PDB-3ic0:
Crystal Structure of liganded hemoglobin in complex with a potent antisickling agent, INN-298
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

Chemicals

ChemComp-OXY:
OXYGEN MOLECULE

ChemComp-HEM:
PROTOPORPHYRIN IX CONTAINING FE

ChemComp-B77:
2-[(2-methoxy-5-methylphenoxy)methyl]pyridine

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsOXYGEN TRANSPORT / Heme protein / hemoglobin / Antisickling agents / Acetylation / Disease mutation / Glycation / Glycoprotein / Heme / Iron / Metal-binding / Phosphoprotein / Polymorphism / Transport / Hypotensive agent / Pyruvate / S-nitrosylation / Vasoactive

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