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Structure paper

TitleStructures of reaction intermediates reveal transient Mg2+-binding events that dynamically coordinate Human Exonuclease I activities
Journal, issue, pagesTo Be Published
Publish dateMay 19, 2021 (structure data deposition date)
AuthorsShi, Y. / Hellinga, H.W. / Beese, L.S.
External linksSearch PubMed
MethodsX-ray diffraction
Resolution2.211 - 3.23 Å
Structure data

PDB-7mxq:
Crystal structure of human exonuclease 1 Exo1 (WT) in complex with 5' recessed-end DNA (r-1)
Method: X-RAY DIFFRACTION / Resolution: 3.23 Å

PDB-7mxr:
Crystal structure of human exonuclease 1 Exo1 (WT) in complex with 5' recessed-end DNA (r-2)
Method: X-RAY DIFFRACTION / Resolution: 3.101 Å

PDB-7mxs:
Crystal structure of human exonuclease 1 Exo1 (WT) in complex with 5' recessed-end DNA (cr)
Method: X-RAY DIFFRACTION / Resolution: 2.798 Å

PDB-7mxt:
Crystal structure of human exonuclease 1 Exo1 (WT) in complex with 5' recessed-end DNA (cmr)
Method: X-RAY DIFFRACTION / Resolution: 3.048 Å

PDB-7mxu:
Crystal structure of human exonuclease 1 Exo1 (WT) in complex with 5' flap DNA (cf2)
Method: X-RAY DIFFRACTION / Resolution: 3.042 Å

PDB-7mxv:
Crystal structure of human exonuclease 1 Exo1 (WT) in complex with 5' recessed-end DNA (ur)
Method: X-RAY DIFFRACTION / Resolution: 2.211 Å

PDB-7mxw:
Crystal structure of human exonuclease 1 Exo1 (WT) in complex with 5' flap DNA (uf1)
Method: X-RAY DIFFRACTION / Resolution: 2.836 Å

PDB-7mxx:
Crystal structure of human exonuclease 1 Exo1 (R92A) in complex with 5' flap DNA (uf4)
Method: X-RAY DIFFRACTION / Resolution: 2.85 Å

Chemicals

ChemComp-MN:
Unknown entry

ChemComp-NA:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-MG:
Unknown entry

ChemComp-CA:
Unknown entry

Source
  • homo sapiens (human)
  • synthetic construct (others)
KeywordsHYDROLASE/DNA / Human Exonuclease 1 Complex with DNA / HYDROLASE / HYDROLASE-DNA complex

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