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Title | Structural Optimization of Cyclic Sulfonamide based Novel HIV-1 Protease Inhibitors to Pico Molar Affinities guided by X-ray Crystallographic Analysis |
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Journal, issue, pages | Tetrahedron, Year 2014 |
Publish date | Aug 21, 2013 (structure data deposition date) |
Authors | Ganguly, A.K. / Alluri, S.S. / Wang, C.H. / Antropow, A. / White, A. / Caroccia, D. / Biswas, D. / Kang, E. / Zhang, L.K. / Carroll, S.S. ...Ganguly, A.K. / Alluri, S.S. / Wang, C.H. / Antropow, A. / White, A. / Caroccia, D. / Biswas, D. / Kang, E. / Zhang, L.K. / Carroll, S.S. / Burlein, C. / Fay, J. / Orth, P. / Strickland, C. |
External links | Tetrahedron / Search PubMed |
Methods | X-ray diffraction |
Resolution | 1.19 - 1.56 Å |
Structure data | PDB-4mc1: PDB-4mc2: PDB-4mc6: PDB-4mc9: |
Chemicals | ChemComp-CL: ChemComp-526: ChemComp-HOH: ChemComp-525: ChemComp-23K: ChemComp-EDO: ChemComp-23L: |
Source |
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Keywords | HYDROLASE/HYDROLASE INHIBITOR / carbamates / drug design / HIV protease inhibitors / protein binding / stereoisomerism / structure-activity relationship / thiazepines / HYDROLASE-HYDROLASE INHIBITOR complex |