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TitleCrystal structure of Trypanosoma cruzi Dihydrofolate Reductase-Thymidylate Synthase in complex with (6S)-5,6,7,8-TETRAHYDROFOLATE
Journal, issue, pagesTo Be Published
Publish dateSep 5, 2016 (structure data deposition date)
AuthorsDi Pisa, F. / Dello Iacono, L. / Bonucci, A. / Mangani, S.
External linksSearch PubMed
MethodsX-ray diffraction
Resolution1.8 Å
Structure data

PDB-5t7o:
Crystal structure of Trypanosoma cruzi Dihydrofolate Reductase-Thymidylate Synthase in complex with (6S)-5,6,7,8-TETRAHYDROFOLATE
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

Chemicals

ChemComp-NAP:
NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE

ChemComp-THG:
(6S)-5,6,7,8-TETRAHYDROFOLATE

ChemComp-UMP:
2'-DEOXYURIDINE 5'-MONOPHOSPHATE

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-HOH:
WATER

Source
  • trypanosoma cruzi (strain cl brener) (eukaryote)
KeywordsOXIDOREDUCTASE / transferase / folate metabolism / trypanosomatidic infections / trypanosoma cruzi

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