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Structure paper

TitleStructure-Guided Loop Grafting Improves Expression and Stability of Influenza Neuraminidase for Vaccine Development
Journal, issue, pagesElife, Year 2025
Publish dateSep 9, 2024 (structure data deposition date)
AuthorsRijal, P. / Wei, L. / Paesen, G.C. / Stuart, D.I. / Howarth, M.R. / Huang, K.Y.A. / Bowden, T.A. / Townsend, A.R.
External linksElife / Search PubMed
MethodsX-ray diffraction
Resolution1.78 - 1.98 Å
Structure data

PDB-9gqq:
influenza neuraminidase N1/19 hybrid
Method: X-RAY DIFFRACTION / Resolution: 1.78 Å

PDB-9gqt:
influenza neuraminidase hybrid N1/09
Method: X-RAY DIFFRACTION / Resolution: 1.94 Å

PDB-9gqx:
influenza neuraminidase mSN1
Method: X-RAY DIFFRACTION / Resolution: 1.98 Å

Chemicals

ChemComp-CA:
Unknown entry

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-HOH:
WATER

Source
  • unidentified influenza virus
KeywordsVIRAL PROTEIN / influenza virus neuraminidase loop grafting / influenza neuraminidase hybrid expression / influenza neuraminidase recombinant expression

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