EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	Dual BET/BRPF1 inhibitors induce morphological alteration and cellular death in various human cancer cell lines
ジャーナル・号・ページ	To be published
掲載日	2023年8月23日 (構造データの登録日)
著者	Cazzanelli, G. / Dalle Vedove, A. / Caflisch, A. / Lolli, G.
リンク	PubMedで検索
手法	X線回折
解像度	1.25 - 1.5 Å
構造データ	PDB-8qal: Crystal Structure of the first bromodomain of BRD4 in complex with acetyl-pyrrole derivative compound 83 手法: X-RAY DIFFRACTION / 解像度: 1.3 Å PDB-8qan: Crystal Structure of the first bromodomain of BRD4 in complex with acetyl-pyrrole derivative compound 79 手法: X-RAY DIFFRACTION / 解像度: 1.25 Å PDB-8qap: Crystal Structure of the first bromodomain of BRD4 in complex with acetyl-pyrrole derivative compound 2 手法: X-RAY DIFFRACTION / 解像度: 1.4 Å PDB-8qar: Crystal Structure of the first bromodomain of BRD4 in complex with acetyl-pyrrole derivative compound 98 手法: X-RAY DIFFRACTION / 解像度: 1.5 Å PDB-8qaz: Crystal Structure of BRPF1 bromodomain in complex with acetyl-pyrrole derivative compound 3 手法: X-RAY DIFFRACTION / 解像度: 1.4 Å PDB-8qb0: Crystal Structure of BRPF1 bromodomain in complex with acetyl-pyrrole derivative compound 2 手法: X-RAY DIFFRACTION / 解像度: 1.45 Å PDB-8qb2: Crystal Structure of BRPF1 bromodomain in complex with acetyl-pyrrole derivative compound 79 手法: X-RAY DIFFRACTION / 解像度: 1.42 Å
化合物	ChemComp-GQX: 2-[4-(3-methyl-4-oxidanylidene-2,5,6,7-tetrahydroisoindol-1-yl)-1,3-thiazol-2-yl]guanidine ChemComp-EDO: 1,2-ETHANEDIOL / エチレングリコ-ル ChemComp-HOH: WATER ChemComp-GKI: 1-[2-methyl-4-(3-methylbutyl)-5-(2-piperazin-1-yl-1,3-thiazol-4-yl)-1~{H}-pyrrol-3-yl]ethanone 化合物画像なし ChemComp-Q9U: Unknown entry ChemComp-GI0: 3-methyl-1-[2-[4-[(4-methyl-1~{H}-pyrazol-3-yl)methyl]piperazin-1-yl]-1,3-thiazol-4-yl]-2,5,6,7-tetrahydroisoindol-4-one 化合物画像なし ChemComp-QA5: Unknown entry ChemComp-NO3: NITRATE ION
由来	homo sapiens (ヒト)
キーワード	TRANSCRIPTION / four helical bundle