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TitleEnhanced antiviral activity by the P2-tris-tetrahydrofuran moiety of GRL-0519, a novel nonpeptidic HIV-1 protease inhibitor (PI), against multi-PI-resistant and highly darunavir-resistant strains of HIV-1.
Journal, issue, pagesTo be Published
Publish dateNov 28, 2014 (structure data deposition date)
AuthorsYedidi, R.S. / Maeda, K. / Aoki, M. / Garimella, H. / Rao, K.V. / Akasapu, S. / Davis, D.A. / Kaufman, J.D. / Das, D. / Wingfield, P.T. ...Yedidi, R.S. / Maeda, K. / Aoki, M. / Garimella, H. / Rao, K.V. / Akasapu, S. / Davis, D.A. / Kaufman, J.D. / Das, D. / Wingfield, P.T. / Amano, M. / Ghosh, A.K. / Mitsuya, H.
External linksSearch PubMed
MethodsX-ray diffraction
Resolution1.955 Å
Structure data

PDB-4rvx:
Crystal structure of multidrug-resistant clinical isolate A02 HIV-1 protease in complex with non-peptidic inhibitor, GRL079
Method: X-RAY DIFFRACTION / Resolution: 1.955 Å

Chemicals

ChemComp-79G:
(4S)-4-amino-N-[(2S,3S)-3-hydroxy-4-{[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino}-1-phenylbutan-2-yl]-3,4-dihydro-2H-chromene-6-carboxamide

ChemComp-HOH:
WATER

Source
  • human immunodeficiency virus 1
KeywordsHYDROLASE/HYDROLASE INHIBITOR / Hydrolase / HYDROLASE-HYDROLASE INHIBITOR complex / HIV-1 PROTEASE-INHIBITOR COMPLEX / GRL079 / NON-PEPTIDIC PROTEASE INHIBITOR

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