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Title | Design and Discovery of 3-Aryl-5-Substituted-Isoquinolin-1- Ones as Potent and Selective Tankyrase Inhibitors |
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Journal, issue, pages | Medchemcommm, Vol. 6, Page 1687-, Year 2015 |
Publish date | Jul 28, 2014 (structure data deposition date) |
Authors | Elliot, R.J. / Jarvis, A. / Rajasekaran, M.B. / Menon, M. / Bowers, L. / Boffey, R. / Bayford, M. / Firth-Clark, S. / Beevers, R. / Aquil, R. ...Elliot, R.J. / Jarvis, A. / Rajasekaran, M.B. / Menon, M. / Bowers, L. / Boffey, R. / Bayford, M. / Firth-Clark, S. / Beevers, R. / Aquil, R. / Kirton, S.B. / Niculescu-Duvaz, D. / Fish, L. / Lopes, F. / Mcleary, R. / Trindade, I. / Vendrell, E. / Munkonge, F. / Porter, R. / Perrior, T. / Springer, C. / Oliver, A.W. / Pearl, L.H. / Ashworth, A. / Lord, C.J. |
External links | Medchemcommm / Search PubMed |
Methods | X-ray diffraction |
Resolution | 2.52 Å |
Structure data | PDB-4uuh: |
Chemicals | ChemComp-ZN: ChemComp-GOL: ChemComp-EDO: ChemComp-T40: ChemComp-HOH: |
Source |
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Keywords | TRANSFERASE / TNKS / INHIBITOR / WNT SIGNALLING |