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TitlePIP2-dependent conformational changes and stabilization of cytoplasmic loop in Cx43/GJA1 gap junction channel
Journal, issue, pagesTo Be Published
Publish dateDec 6, 2023 (structure data deposition date)
AuthorsLee HJ / Cha HJ / Woo JS
External linksSearch PubMed
MethodsEM (single particle)
Resolution3.0 - 3.1 Å
Structure data

EMDB-38220: Consensus map of Cx43/GJA1 gap junction channel in the presence of diC8-PIP2 (8-fold molar excess)
Method: EM (single particle) / Resolution: 3.1 Å

EMDB-38221: Consensus map of Cx43/GJA1 gap junction channel in the presence of diC8-PIP2 (16-fold molar excess)
Method: EM (single particle) / Resolution: 3.0 Å

38223

8xbm

EMDB-38223, PDB-8xbm:
Structure of Cx43/GJA1 gap junction intercellular channel in complex with diC8-PIP2
Method: EM (single particle) / Resolution: 3.0 Å

Chemicals

ChemComp-PIO:
[(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate

Source
  • homo sapiens (human)
KeywordsMEMBRANE PROTEIN / Cx43 gap junction channel / PIP2 / Cytoplasmic loop / Opening

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