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Structure paper

TitlePPARgamma-RXRalpha(S427F) heterodimer in complex with SRC-1, rosiglitazone, and 9-cis-retanoic acid
Journal, issue, pagesTo Be Published
Publish dateApr 21, 2016 (structure data deposition date)
AuthorsKorpal, M. / Zhu, P. / Bloudoff, K. / Larsen, N.A. / Fekkes, P.
External linksSearch PubMed
MethodsX-ray diffraction
Resolution1.98 Å
Structure data

PDB-5ji0:
PPARgamma-RXRalpha(S427F) heterodimer in complex with SRC-1, rosiglitazone, and 9-cis-retanoic acid
Method: X-RAY DIFFRACTION / Resolution: 1.98 Å

Chemicals

ChemComp-9CR:
(9cis)-retinoic acid / anticancer, antineoplastic*YM

ChemComp-BRL:
2,4-THIAZOLIDIINEDIONE, 5-[[4-[2-(METHYL-2-PYRIDINYLAMINO)ETHOXY]PHENYL]METHYL]-(9CL)

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / PPARG / RXRa / SRC1 / agonist / nuclear hormone receptor / heterodimer / bladder cancer / muscle invasive bladder cancer / MIBC

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