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TitleIdentification of a Monovalent Pseudo-Natural Product Degrader Class Supercharging Degradation of IDO1 by its native E3 KLHDC3
Journal, issue, pagesTo be published
Publish dateJun 11, 2025 (structure data deposition date)
AuthorsLucas, B.
External linksSearch PubMed
MethodsX-ray diffraction
Resolution2.1 Å
Structure data

PDB-9ris:
Crystal structure of human IDO1 in complex with iDeg-1
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

Chemicals

ChemComp-PGE:
TRIETHYLENE GLYCOL

PDB-1jgl:
Crystal structure of immunoglobulin Fab fragment complexed with 17-beta-estradiol

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsOXIDOREDUCTASE / IDO1 / heme-binding protein / pseudo-natural product

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