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TitleStructural insights into inhibitor mechanisms on immature HIV-1 Gag lattice revealed by high-resolution in situ single-particle cryo-EM
Journal, issue, pagesTo Be Published
Publish dateOct 23, 2024 (structure data deposition date)
AuthorsWu C / Meuser ME / Rey JS / Meshkin H / Yang R / Devarkar SC / Freniere C / Shi J / Aiken C / Perilla JR / Xiong Y
External linksSearch PubMed
MethodsEM (single particle)
Resolution2.71 Å
Structure data

47475

9e39

EMDB-47475, PDB-9e39:
Gag CA-SP1 (T8I) immature lattice bound with Bevirimat from enveloped virus like particles
Method: EM (single particle) / Resolution: 2.71 Å

Chemicals

ChemComp-2I4:
3alpha-[(3-carboxy-3-methylbutanoyl)oxy]-8alpha,9beta,10alpha,13alpha,17alpha,19beta-lup-20(29)-en-28-oic acid

ChemComp-IHP:
INOSITOL HEXAKISPHOSPHATE

ChemComp-HOH:
WATER

Source
  • human immunodeficiency virus type 1 (hbx2 isolate)
KeywordsVIRAL PROTEIN / HIV-1 / Gag / CA-SP1 / Inhibitor / virion assembly

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